Which PDE5 inhibitor works best?

Which PDE5 inhibitor works best?

What is the definition of PDE5 inhibitors?

It influences blood flow and cell signaling in the body. PDE5 inhibitors prohibit the PDE5 enzyme from functioning. This inhibition causes the blood arteries to relax, increasing blood flow. PDE5 inhibitors can be used to treat erectile dysfunction and pulmonary hypertension.

PDE5 inhibitors enhance blood flow to the penis, which improves erectile function in persons with ED.

  • Managing blood flow to the arteries of the lungs
  • Increased blood flow to the lungs
  • Decrease blood pressure

How do they operate?

PDE5 enzymes are molecules that speed up and facilitate chemical reactions. In humans, PDEs are classified into numerous categories, each having its number to differentiate it. These various forms of PDEs are often found in distinct locations throughout your body.

PDE5 inhibitors that are on prescription

There are a variety of PDE5 inhibitor medications available, which are typically taken in tablet form.

There are 4 main types of PDE5 inhibitors:

  1. Sildenafil (Viagra)

Sildenafil (Viagra) is a reasonably priced medication used to treat erection difficulties in males. It is also used to treat pulmonary arterial hypertension, a severe heart and lung disease. This drug is more popular than similar medications. It’s available in both generic and brand forms. Most Medicare and insurance programs cover generic sildenafil, although some pharmacies provide coupons or cash discounts.

  1. Tadalafil (Cialis)

Cialis (tadalafil) is a costly medication used to treat erectile dysfunction in males. It may also be used to treat prostatic hypertrophy. This drug is slightly more popular than similar medications. Most Medicare and insurance plans do not cover Cialis, however manufacturer and pharmacy coupons can help reduce the cost.

  1. Vardenafil (Levitra)

Vardenafil (Staxyn) is a costly medication used to treat erection issues in males. This medication is less popular than similar medications. Staxyn presently has no generic equivalents. Most Medicare and insurance plans do not cover this, although manufacturer and pharmacy coupons can help offset the cost.

  1. Avanafil (Stendra)

Stendra is used to address erection issues in males. This medicine is less popular than related drugs. There are no generic alternatives to Stendra right now. Check out our savings recommendations for copay cards, assistance programs, and other cost-cutting strategies. Most Medicare and insurance programs do not cover Stendra.

How Cialis and Viagra Function

Cialis and Viagra are phosphodiesterase type 5 (PDE5) inhibitors. PDE5 is a key enzyme involved in erections and one of the most common causes of erectile dysfunction.

When your penile nerves are stimulated, you have an erection. When this happens, the muscles around two cylinder-shaped pieces of tissue in your penis, known as the corpora cavernosa, relax and fill with blood.

When you have ED, nerves in your brain and penis do not communicate properly, causing blood to flow improperly into your penis.

Viagra and Cialis inhibit PDE5 and relax the blood vessel walls. This facilitates blood flow into your penis tissues, resulting in an erection.

How do PDE5 inhibitors function?

PDE5 inhibitors vasodilate the penis, which means they relax the blood vessels and enhance blood flow.

The Science of Erections

The process of achieving an erection is difficult. When sexually aroused, your parasympathetic nervous system is engaged. This brain activity causes the release of a chemical called nitric oxide (NO), which boosts the creation of another molecule called cyclic GMP. PDE5 is an enzyme that degrades cyclic GMP molecules and reverses the erection process. PDE5 inhibitors, on the other hand, have a structure identical to cyclic GMP and bind to PDE5 to prevent its breakdown. This action boosts the activity of NO and aids in blood flow.

What foods include PDE5 inhibitors?

PDE5 inhibitors are naturally found in several plants. These plants are frequently offered as supplements and advertised for the treatment of erectile dysfunction or the enhancement of male vitality.

The FDA Trusted Source advises against using dietary supplements to treat ED since many of these products include undeclared components that could be dangerous. The safety and efficacy of these supplements have also not been well explored.

Risks and side effects

People who take nitrates should avoid PDE5 inhibitors. When both drugs are used together, blood pressure can drop dramatically.

  • Headaches
  • Flushing
  • Symptoms resembling those of the common cold
  • Stomach upset
  • Muscle and back pain
  • Sudden loss of hearing
  • Prolonged or painful

PDE5 inhibitor-containing substances

Some herbs include PDE5 inhibitors, which can be found as supplements or herbal medicines.

However, herbs and supplements Trusted Source may contain undisclosed substances, induce serious side effects, or combine with other medications.

The FDA Trusted Source cautions that herbal or alternative therapies for illnesses such as ED may contain active components found in prescription medicines.

Before taking medications and supplements that include PDE5 inhibitors or promise benefits similar to PDE5 inhibitor prescription drugs, see a doctor.

When to call a doctor

If a person is having difficulty obtaining and maintaining an erection, they should consult a doctor.

  • Consider the frequency and duration of erections, as well as any stress-related issues that may hinder erections.
  • How frequently a person has sexual passion.
  • Whether the individual is already trying therapies.
  • If the individual has a spouse, whether they are willing to participate in treatment
  • Symptoms of a heart attack. These symptoms include chest pain, difficulty breathing, perspiration, dizziness, nausea, and so forth.
  • This is an erection that lasts at least four hours or fluctuates throughout multiple hours. Priapism develops without sexual excitement and can be unpleasant or painful.
  • Loss of eyesight or hearing. Any sudden decline in your vision or hearing needs emergency medical care. If you wait too long to get assistance, your problems may become permanent.

Healthcare experts may also inquire about a person’s risk factors, such as type 2 diabetes or hypertension. They may also inquire whether the individual smokes, drinks, uses drugs, or participates in regular activities.

Are PDE5 inhibitors often prescribed?

PDE inhibitors, particularly PDE-5 inhibitors, are widely prescribed for the treatment of erectile dysfunction. In 2019, the top two PDE inhibitor drugs, sildenafil and tadalafil, received more than 4 million prescriptions alone. Both are in the top 300 most regularly given drugs in the United States.

Do PDE5 inhibitors have any interactions with other medications?

PDE inhibitors can interact with a wide range of drugs, particularly those affecting the heart, lungs, or circulatory systems. Your healthcare practitioner can provide you with more information and tell you what to avoid when using these medications.


Do not use Cialis and Viagra simultaneously. Combining these will not only not relieve ED symptoms, but it may also be harmful.

Discuss with your doctor any worries you have regarding your ED and its causes. In some circumstances, combining medicine with lifestyle changes is the most effective strategy to improve ED symptoms.

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